Post-PCI Bleeding Linked to Increased In-Hospital Mortality

An estimated 12.1 percent of deaths were related to bleeding complications
Post-PCI Bleeding Linked to Increased In-Hospital Mortality

WEDNESDAY, March 13 (HealthDay News) -- Post-percutaneous coronary intervention (PCI) bleeding events are associated with an increased risk of in-hospital mortality, according to a study published in the March 13 issue of the Journal of the American Medical Association.

Adnan K. Chhatriwalla, M.D., from Saint Luke's Mid America Heart Institute in Kansas City, Mo., and colleagues analyzed data from 3,386,688 PCI procedures in the CathPCI Registry performed in the United States between 2004 and 2011. Propensity-matched analysis was conducted to calculate the number needed to harm (NNH) for bleeding-related mortality.

The researchers found that, in total, there were 57,246 bleeding events (1.7 percent) and 22,165 in-hospital deaths (0.65 percent). For mortality related to major bleeding, the adjusted population attributable risk was 12.1 percent in the entire CathPCI cohort. Within the propensity-matched population comprising 56,078 procedures with a major bleeding event and 224,312 controls, major bleeding correlated with increased in-hospital mortality (5.26 percent versus 1.87 percent; NNH, 29). The correlation was observed in all strata of preprocedural bleeding risk (low: 1.62 percent versus 0.17 percent; NNH, 69; intermediate: 3.27 percent versus 0.71 percent; NNH, 39; and high: 8.16 percent versus 3.45 percent; NNH, 21). The NNH was lower for nonaccess site bleeding, although both access-site (2.73 percent versus 1.87 percent; NNH, 117) and nonaccess-site bleeding (8.25 percent versus 1.87 percent; NNH, 16) were associated with increased in-hospital mortality.

"In a large registry of patients undergoing PCI, postprocedural bleeding events were associated with increased risk of in-hospital mortality, with an estimated 12.1 percent of deaths related to bleeding complications," write the authors.

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)

Related Stories

No stories found.
logo
www.healthday.com