Peripheral Globules, Related Lesion Dynamics Predict Outcomes in Melanocytic Nevi

WEDNESDAY, Aug. 12, 2026 (HealthDay News) -- Peripheral globules in melanocytic nevi change with time, and the related lesion dynamics are independently associated with a clinically significant histopathologic end point, according to a study published online Aug. 6 in the Journal of the American Academy of Dermatology.Kaan Gündüz, M.D., from the Ankara University School of Medicine in Turkey, and colleagues examined whether longitudinal evolution of peripheral globules and related lesion dynamics predict histopathologic outcomes in a single-center ambispective cohort study. The cohort included 215 patients with 1,923 melanocytic lesions who underwent sequential digital dermoscopy.The researchers found that 46.9 percent of lesions showed complete globule resolution during follow-up. Persistent globules were associated with an increased risk compared with resolution, including stable globules and increasing globules (adjusted odds ratios, 3.91 and 4.18, respectively). Independent associations with a clinically significant histopathologic end point were seen for increasing pigmentation (adjusted odds ratio, 6.33), faster growth (adjusted odds ratio, 1.15 per 0.1 mm2/month), and personal history of melanoma (adjusted odds ratio, 7.65), while this association was not seen for age."Integrating these lesion-level dynamics with patient-level risk factors may improve differentiation between benign maturing nevi and lesions requiring intervention, complementing standard sequential dermoscopic assessment while supporting earlier melanoma detection and fewer unnecessary excisions," the authors write.Abstract/Full Text (subscription or payment may be required).Sign up for our weekly HealthDay newsletter

Peripheral Globules, Related Lesion Dynamics Predict Outcomes in Melanocytic Nevi

Related Stories

Fish Oil Supplement Added to Isotretinoin Noninferior for Treating Acne

Dermatologist-Performed Skin Cancer Screening Has Low Melanoma Detection Rate

Vitiligo Linked to Significant Psychosocial Challenges

Dermatoscopy, Close-Up Imaging Provide Complementary Diagnostic Insight