Researchers Win Nobel Prize for Uncovering How the Immune System Protects Itself

Key TakeawaysThree scientists have won the 2025 Nobel Prize for discovering regulatory T-cellsTheir research revealed how the immune system prevents autoimmune diseaseThe discovery has led to new treatments for autoimmune disorders, cancer and transplant recovery.TUESDAY, Oct. 7, 2025 (HealthDay News) — Three immunologists have won the 2025 Nobel Prize in Physiology or Medicine for uncovering how the immune system prevents itself from attacking the body.The discovery has opened new paths for treatment.Immunologists Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered a special group of immune cells called regulatory T-cells.These cells help keep the immune system balanced, stopping it from harming the body. Their research revealed a key part of how the immune system functions.“Their discoveries have been decisive for our understanding of how the immune system functions and why we do not all develop serious autoimmune diseases,” Nobel Committee Chair Olle Kämpe said.The three scientists will share 11 million Swedish kronor (about $1.1 million). Brunkow is based at the Institute for Systems Biology in Seattle; Ramsdell at Sonoma Biotherapeutics in San Francisco and Seattle; and Sakaguchi is a professor at Osaka University in Japan.Sonoma Biotherapeutics CEO Jeff Bluestone told The Wall Street Journal that Ramsdell, who had been backpacking off the grid in Idaho, learned of his Nobel Prize on Monday evening after returning from his trip. Earlier in the day, colleagues had been unable to reach him, Bluestone said.In the 1990s, Sakaguchi discovered that removing the thymus gland from newborn mice caused their immune systems to attack their own organs. He later found that a small group of cells, now known as regulatory T-cells, stopped the immune system from attacking.In 2001, Brunkow and Ramsdell identified the Foxp3 gene, which helps these regulatory cells develop properly. When this gene is damaged, the immune system can start attacking the body’s own tissues.“It was really a molecular slog, to get to that exact mutation,” Brunkow explained. “It was just a very small genetic alteration that results in quite a profound change in the immune system.”The winners’ work has led to new areas of research aimed at treating autoimmune diseases, cancer and complications after organ transplants.“The ability to manipulate these cells so that they can become powerful, specific therapeutics is really the promise of the field,” Bluestone told The Wall Street Journal.Sakaguchi, who called the award “a happy surprise,” said he plans to continue exploring how to fine-tune immune responses to help the body fight cancer.More informationJohns Hopkins Medicine has more on the immune system.SOURCE: The Wall Street Journal, Oct. 6, 2025.What This Means For YouThis discovery could soon lead to better treatments for autoimmune diseases, cancer and organ transplant patients..Sign up for our weekly HealthDay newsletter