The Mystery to Beethoven’s Death May Be Over Thanks to Genetic Research

It’s been a mystery since 1827 what killed Ludwig von Beethoven. Now, modern-day genetics may provide some clues. A team of international scientists sequenced the composer’s genome using five locks of his hair. The samples were obtained from collectors around the world and underwent extensive authenticity testing.

The musical genius was known or suspected to suffer from hearing loss, gastrointestinal problems, jaundice, and cirrhosis of the liver. The scientists discovered evidence of an infection with hepatitis B and several significant genetic risk factors for liver disease. They suggest that it’s possible alcohol consumption combined with Beethoven’s genetic risk caused the cirrhosis.

No genetic explanation was found for his gastrointestinal complaints, but based on the data, the scientists say it’s unlikely that celiac disease or lactose intolerance contributed. The research also failed to reveal a clear genetic reason for Beethoven’s hearing loss, although a link could not be ruled out.

One author notes, “We cannot say definitely what killed Beethoven, but we can now at least confirm the presence of significant heritable risk and an infection with the hepatitis B virus.”