It’s estimated more than 20% of U.S. adults use CBD for chronic pain, stress, anxiety and insomnia.But a new study warns even small amounts of the chemical found in marijuana can lead to elevated liver enzymes.CBD or “cannabidiol” is a naturally occurring compound derived from the cannabis sativa plant. It does not cause the “high” or sense of euphoria often associated with THC, the main psychoactive ingredient in marijuana.This randomized, double-blind clinical trial included 201 healthy adults who were administered a low dose of CBD or placebo for 28 days.5.6% of the participants experienced liver enzyme elevations greater than 3 times the upper limit of normal, according to the resultsAbout 5% met the defined criteria for potential liver injury , but no participants experienced jaundice or clinical symptoms related to impaired liver function. And researchers say their liver enzymes returned to normal within 1 to 2 weeks following discontinuation.While longer studies are needed to confirm the results, the authors recommend clinicians screen patients with elevated liver enzymes for CBD use.Source: JAMA Internal MedicineAuthor Affiliations: U.S. Food and Drug Administration, Los Angeles General Medical Center, Spaulding Clinical Research .Sign up for our weekly HealthDay newsletter