People taking weight-loss drugs… including popular GLP-1s … may regain a significant amount of weight within months of stopping their medication.In a new study, researchers reviewed 11 clinical trials investigating weight rebound after discontinuation of an anti-obesity med.Overall, they found the pounds started creeping back on after 4 weeks and reached significant levels by 8 weeks.The studies included about 1,600 patients who stopped treatment and 900 in control groups… and focused on 5 types of anti-obesity meds.GLP-1 Receptor AgonistsGLP-1 and GLP dual RasOrlistatPhentermine-TopiramateNaltexone-Bupriopion The analysis found significant increases in weight after 8, 12 and 20 weeks of discontinuation, followed by a plateauing.But by the 12-week mark, major increases were only observed in patients using GLP-1 drugs, according to the researchers.The authors say, “While the amount of weight regain varies depending on the specific drug, there is a broad trend in associated weight regain after the course of medication concluded.”Source: BMC MedicineAuthor Affiliations: Peking University People’s Hospital .Sign up for our weekly HealthDay newsletter