MONDAY, April 10 (HealthDay News) -- Patients with lobular carcinoma in situ are more likely to develop invasive breast cancer than those with ductal carcinoma in situ, according to research published online April 10 in Cancer.
Christopher I. Li, M.D., Ph.D., of the Fred Hutchinson Cancer Research Center in Seattle, and colleagues analyzed data on 37,692 patients with ductal carcinoma in situ (DCIS) and 4,490 patients with lobular carcinoma in situ (LCIS).
LCIS patients were more likely to develop invasive cancer than DCIS patients, and 5.3 times as likely to develop invasive lobular carcinoma. DCIS patients who were under age 50, black or Hispanic were 1.6, 2.7 and 2.3 times as likely to develop stage III or stage IV cancer as women aged 50 to 59 and those who were non-Hispanic whites, respectively.
"Screening young DCIS patients more frequently and improving the follow-up care of blacks and Hispanic whites with DCIS may reduce their risk of advanced-stage breast cancer," the authors write. "In addition, LCIS may be a precursor rather than just an ambiguous risk factor for invasive breast cancer, and, therefore, localized treatment for LCIS may be warranted."
Abstract
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