MONDAY, June 2 (HealthDay News) -- The ketosamine FruHis, found in tomato powder, may interact with lycopene to offer protection against prostate cancer, according to research from rat studies published in the June 1 issue of Cancer Research.
Valeri V. Mossine, Ph.D., of the University of Missouri-Columbia, and colleagues write that ketosamines are non-digestible carbohydrate derivatives formed during the dehydration of tomatoes. They found that FruHis suppressed proliferation of MAT-LyLu rat prostate adenocarcinoma cells in vitro when combined with lycopene, and also inhibited tumor formation in Copenhagen rats implanted with the cells.
The researchers also fed a diet supplemented with tomato paste, tomato powder, or tomato paste with FruHis, or a control diet to Wistar-Unilever rats in which prostate cancer was induced. The proportions of dying animals with macroscopic prostate tumors in these groups were 39 percent, 43 percent, 18 percent and 63 percent, respectively.
"This (antitumorigenic) result may introduce an additional intrigue into an ongoing dispute over the beneficial effects of dietary lycopene and tomato products in lowering the risk of prostate cancer because it suggests the presence of a potential chemopreventive agent(s) in tomato products prepared by rehydration of tomato powder. Whereas it is not possible to retrospectively evaluate ketosamine content in tomato products from the numerous published intervention and epidemiologic studies, the assessment study of the clinically relevant effects of ketosamines from dietary tomato products in humans is warranted," the authors conclude.
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