MONDAY, Jan. 26 (HealthDay News) -- New formulas for estimating glomerular filtration rate (GFR) in children with chronic kidney disease can provide results comparable to the best equations for adults, according to research published online Jan. 21 in the Journal of the American Society of Nephrology.
George J. Schwartz, M.D., of the University of Rochester School of Medicine in Rochester, N.Y., and colleagues used data from 349 children in the Chronic Kidney Disease in Children cohort to create equations to estimate GFR. In these children, iohexol plasma disappearance was used as the gold standard in measuring GFR (iGFR).
The best formula utilized height, serum creatinine, cystatin C, blood urea nitrogen and gender, the researchers report. This formula put 87.7 percent of estimated GFR values within 30 percent of the iGFR, and 45.6 percent within 10 percent of iGFR, according to the authors. When applied to a group of 168 patients from the cohort at follow-up, this model performed favorably compared to previously published equations, and 83 and 41 percent of the estimated GFR values were within 30 and 10 percent, respectively, of iGFR values, the report indicates.
"In sum, we have developed new formulas to estimate GFR in children with chronic kidney disease," the authors write. "Such formulas performed well in a test group of individuals who had a second iGFR measurement. For the clinician who provides the height of the child, our equations can estimate GFR from the standard chemistry panel, similar to what is provided for adults using the Modification of Diet in Renal Disease equation at most clinical chemistry laboratories."
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