THURSDAY, Oct. 12 (HealthDay News) -- In patients with type 2 diabetes, a polymorphism in the alpha-adducin 1 (ADD1) gene is associated with an increased risk of macrovascular complications and death, according to a brief report published in the October issue of Diabetes.
Cornelia M. van Duijn, Ph.D., of the Erasmus Medical Center in Rotterdam, the Netherlands, and colleagues identified ADD1 polymorphism in 6,471 white, Dutch study participants, including 599 with type 2 diabetes at baseline.
The researchers found that diabetic ADD1 TT carriers had a 2.57 higher prevalence of hypertension than ADD1 GG carriers, and that homozygous T carriers also had a higher mean common carotid intima media thickness (mean difference 0.05 mm). They also found that homozygous T carriers had a 1.83 times higher risk of mortality than the GG carriers, but that this increased risk was only present among TT carriers who did not use diabetes medications.
"The study indicates that the ADD1 polymorphism could be useful in identifying hypertensive type 2 diabetic patients with a high risk of mortality," the authors conclude.
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