Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for June 2010. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Group of Older Men Have Cardio Events With Testosterone Gel
WEDNESDAY, June 30 (HealthDay News) -- Older men with limited mobility have improved muscle strength but an increased risk of cardiovascular events when they receive testosterone gel supplementation, according to research published online June 30 in the New England Journal of Medicine.
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Adult Obesity Rate Increases in 28 States
WEDNESDAY, June 30 (HealthDay News) -- In the past year, the adult obesity rate increased in 28 states, and there are marked differences in obesity rates by region, race, and income, according to a report published June 29 by the Trust for America's Health and the Robert Wood Johnson Foundation.
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Doctors Agree Malpractice Fears Drive Overuse of Tests
MONDAY, June 28 (HealthDay News) -- A large majority of physicians agree that the practice of defensive medicine -- stemming from malpractice concerns -- is responsible for an overuse of medical tests and procedures, according to a research letter in the June 28 issue of the Archives of Internal Medicine.
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Two Studies Demonstrate Cardiac Risks of Rosiglitazone
MONDAY, June 28 (HealthDay News) -- New evidence suggests that rosiglitazone is associated with an increased risk of adverse cardiovascular outcomes, according to two studies published online June 28 in the Journal of the American Medical Association and the Archives of Internal Medicine. The studies were released online ahead of publication because of their relevance to an upcoming U.S. Food and Drug Administration meeting intended to review the safety of rosiglitazone.
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Diabetes May Complicate COPD Hospital Admissions
THURSDAY, June 24 (HealthDay News) -- Patients admitted to the hospital with an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) who have comorbid diabetes mellitus (DM) have trends toward longer hospital length of stay and an increased risk of death compared with those without DM, according to research published online June 4 in Respirology.
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Weight Control Important for Diabetes Risk in Later Years
TUESDAY, June 22 (HealthDay News) -- In older adults, body fat and weight gain after the age of 50 are associated with a higher risk of diabetes, according to research published in the June 23/30 issue of the Journal of the American Medical Association.
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Flame Retardant Affects Thyroid Levels in Pregnant Women
TUESDAY, June 22 (HealthDay News) -- In pregnant women, blood levels of polybrominated diphenyl ether (PBDE) are associated with lower levels of thyroid-stimulating hormone and higher odds of subclinical hyperthyroidism, according to research published online June 21 in Environmental Health Perspectives.
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Strict Diagnostic Criteria Define Late-Onset Hypogonadism
WEDNESDAY, June 16 (HealthDay News) -- Using a concise definition of late-onset hypogonadism which includes the presence of specific sexual symptoms as well as a strict laboratory testosterone level cut-point in older men can identify those men who truly need testosterone replacement therapy, according to research published online June 16 in the New England Journal of Medicine.
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Consensus Statement Explores Diabetes-Cancer Link
WEDNESDAY, June 16 (HealthDay News) -- Having type 2 diabetes is associated with an increased risk of several types of cancer, and the increased risk may be due to shared risk factors, though more research is needed to definitively answer many ongoing questions, according to a consensus report released by the American Diabetes Association and the American Cancer Society and published online June 16 in CA: A Cancer Journal for Clinicians.
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GLP-1's Effects Similar in Those With, Without Diabetes
WEDNESDAY, June 16 (HealthDay News) -- In patients with well-controlled type 2 diabetes, the effects of enteral stimuli and endogenous glucagon-like peptide-1 (GLP-1) on insulin release are similar to those in individuals without diabetes, according to research published in the June issue of Diabetes.
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Substituting Brown for White Rice Reduces Diabetes Risk
TUESDAY, June 15 (HealthDay News) -- Substituting brown rice, or other whole grains, for white rice in a person's diet can lower their risk for type 2 diabetes, according to research published in the June 14 issue of the Archives of Internal Medicine.
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HbA1c Levels Found Higher in Blacks Than Whites
TUESDAY, June 15 (HealthDay News) -- Black individuals have higher hemoglobin A1c levels than whites across the spectrum from normal glucose tolerance to diabetes, and as glucose intolerance worsens, the differences become greater, according to research published in the June 15 issue of the Annals of Internal Medicine.
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ARBs Linked to Modestly Higher Risk of Cancer Diagnosis
MONDAY, June 14 (HealthDay News) -- Angiotensin-receptor blockers (ARBs) appear to be associated with a modest increase in risk of a new cancer diagnosis, according to research published online June 14 in The Lancet Oncology.
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Less Education Linked to Higher Mortality in Diabetes
MONDAY, June 14 (HealthDay News) -- The mortality risk among adults with diabetes differs greatly by educational level, and although the relative disparities in this population are not as strong as those in adults without diabetes, their absolute impact is greater, according to a study in the June issue of Diabetes Care.
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Metformin in Diabetes Linked to Lower Breast Cancer Risk
FRIDAY, June 11 (HealthDay News) -- In women with type 2 diabetes, long-term metformin use is associated with a lower risk of breast cancer, according to research published in the June issue of Diabetes Care.
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Aspirin Found Cost-Effective in Newly Diagnosed Diabetes
FRIDAY, June 11 (HealthDay News) -- In individuals age 40 and older who have been newly diagnosed with type 2 diabetes, regular aspirin use is a cost-effective strategy, according to a study in the June issue of Diabetes Care.
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Intensive Program Beats Usual Care for Diabetes Patients
THURSDAY, June 10 (HealthDay News) -- An intensive lifestyle intervention (ILI) program that restricts calories and increases exercise is able to improve cardiovascular disease (CVD) risk factors and reduce medication use and costs for individuals with type 2 diabetes better than usual care, according to a study in the June issue of Diabetes Care.
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Year of Weekly Exenatide Beneficial in Type 2 Diabetes
THURSDAY, June 10 (HealthDay News) -- In patients with type 2 diabetes, a once-weekly formulation of exenatide is associated with sustained improvements in glycemic control and body weight over 52 weeks, and patients who switch from a twice-daily to a once-weekly regimen have further improvements in A1C and fasting plasma glucose, according to research published in the June issue of Diabetes Care.
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Insulin Resistance With Normal BMI Linked to Mortality Risk
THURSDAY, June 10 (HealthDay News) -- In adults of normal weight without diabetes, insulin resistance -- as measured with the homeostasis model assessment for insulin resistance (HOMA-IR) -- is associated with all-cause mortality, according to research published in the June issue of Diabetes Care.
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Genetic Variants May Affect Vitamin D Concentrations
THURSDAY, June 10 (HealthDay News) -- Vitamin D status appears to be affected by variants near genes involved in cholesterol synthesis, hydroxylation and vitamin D transport, with genetic variations at these sites associated with an increased risk of vitamin D insufficiency, according to a study published online June 10 in The Lancet.
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Short Stature Associated With Higher Heart Disease Risk
WEDNESDAY, June 9 (HealthDay News) -- Being short is associated with a higher risk of coronary heart disease morbidity and mortality than being tall, according to a systematic review and meta-analysis published online June 8 in the European Heart Journal.
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In Utero Exposure to Chemicals May Cause Breast Cancer
WEDNESDAY, June 9 (HealthDay News) -- Prenatal exposure to endocrine-disrupting chemicals found in the environment can cause overexpression of a protein linked to the development of breast cancer in adulthood, according to a mouse study published online May 15 in Hormones & Cancer.
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Fitness Trends Predictive of Diabetes Development
WEDNESDAY, June 9 (HealthDay News) -- People who increase their cardiorespiratory fitness level over time are less likely to develop type 2 diabetes than those who lose fitness, according to research published in the June issue of Diabetes Care.
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Fatal Medication Errors Rise in July at Teaching Hospitals
TUESDAY, June 8 (HealthDay News) -- In July there is a significant increase in fatal medication errors at medical institutions, and this spike is at least partly due to the arrival of new medical residents, according to a study published online May 29 in the Journal of General Internal Medicine.
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Risk Factors Up Odds of Plaque Progression Despite Low LDL
TUESDAY, June 8 (HealthDay News) -- Several independent risk factors, including baseline percent atheroma volume (PAV) and the presence of diabetes, are associated with the likelihood of continued progression of disease in individuals who have achieved very low levels of low-density lipoprotein cholesterol (LDL-C), according to research published in the June 15 issue of the Journal of the American College of Cardiology.
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Many Hospital Patients Readmitted Within Two Years
MONDAY, June 7 (HealthDay News) -- Approximately 25 percent of hospital patients were readmitted to the hospital within a two-year period for the same conditions that prompted their initial admission, according to a recent report from the Agency for Healthcare Research and Quality (AHRQ).
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Many on Bisphosphonates Lack Information About the Drugs
FRIDAY, June 4 (HealthDay News) -- Many individuals taking bisphosphonates are unfamiliar with potential adverse events associated with treatment and with the duration of treatment, according to a study in the May 1 issue of the Journal of the American Dental Association.
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Combination Therapy Cuts Risk of Type 2 Diabetes Onset
THURSDAY, June 3 (HealthDay News) -- Low doses of rosiglitazone and metformin given in combination can substantially reduce the risk of progression to type 2 diabetes in people with impaired glucose tolerance who are at risk for the disease, according to a study published online June 3 in The Lancet.
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Prolia Approved for Postmenopausal Women With Osteoporosis
WEDNESDAY, June 2 (HealthDay News) -- The injected drug Prolia (denosumab) has been approved by the U.S. Food and Drug Administration to treat postmenopausal women at high risk of bone fracture due to osteoporosis.
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