MONDAY, Jan. 19 (HealthDay News) -- Type 2 diabetes patients have a unique pattern of protein expression in their saliva, and many of these proteins have a role in metabolism, according to a study published Jan. 2 in the Journal of Proteome Research.
Paturi V. Rao, of Nizam's Institute of Medical Sciences University in Hyderabad, India, and colleagues characterized the pattern of protein expression, or proteome, in the saliva of patients with type 2 diabetes and compared this proteome with that of nondiabetic individuals. A comprehensive approach was used to identify saliva proteins, including fractionation and mass spectroscopy. Selected proteins were validated using biochemical techniques for their potential as diabetes biomarkers.
A total of 487 unique proteins were identified in the saliva samples. Thirty-three percent of them were newly identified. Of these, 65 proteins were expressed differentially in patients with diabetes (more than a twofold difference in abundance compared with control samples). When many of these differentially expressed proteins were validated, a number of them were found to be important for regulating metabolism and immune response.
"As recent studies have shown that early and multifactorial intervention in DM prevents cardiovascular complications and mortality, advances in understanding molecular aspects of preclinical diabetes will further facilitate accurate diagnosis and early intervention," the authors conclude.
Abstract
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