THURSDAY, June 22 (HealthDay News) -- Polymorphisms in the angiotensin I-converting enzyme (ACE) gene predict muscle growth and strength response to resistance training but mostly in untrained muscles, according to a report in the June issue of Medicine & Science in Sports & Exercise.
Linda S. Pescatello, Ph.D., from the University of Connecticut in Storrs, and colleagues conducted unilateral resistance training in 631 genotyped subjects to determine the association between insertion (I)/deletion (D) polymorphisms in the ACE gene and bicep muscle strength and size response. Previous studies have suggested that the I allele is linked to endurance while a D allele correlates with strength.
The maximal voluntary contraction increases were greater in subjects with the II or ID genotypes compared with DD genotypes, but these changes were most apparent in the untrained arms. "ACE ID genotype is associated with the contralateral effects of unilateral resistance training, perhaps more so than with the muscle strength and size adaptations that result from resistance training," the authors write.
"The most interesting results were for the untrained contralateral limb," explains Stephen M. Roth from the University of Maryland in College Park, in an accompanying editorial. "The results indicate that the response of muscle to resistance training is not highly related to the ACE I/D polymorphism, whereas the contralateral effects of unilateral training are associated with the presence of the D-allele."
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