Review: MMR, MMRV, MMR+V Vaccines Are Effective, Safe

Review confirms vaccines effective for preventing disease, not associated with increased risk for autism

FRIDAY, April 24, 2020 (HealthDay News) -- Measles, mumps, and rubella (MMR) vaccines and MMR vaccines with varicella are effective and safe, according to an updated review published online April 20 in the Cochrane Database of Systematic Reviews.

Carlo Di Pietrantonj, from Azienda Sanitaria Locale ASL AL in Alessandria, Italy, and colleagues examined the effectiveness, safety, and adverse effects associated with MMR, MMR vaccine and varicella vaccine (MMR+V), or a vaccine including measles, mumps, rubella, and varicella strains (MMRV) in healthy children up to 15 years of age. Data were included from 138 studies with 23,480,668 participants.

The researchers found that vaccine effectiveness for preventing measles was 95 and 96 percent after one and two doses, respectively (relative risks, 0.05 and 0.04). The effectiveness of Jeryl Lynn containing MMR vaccine in preventing mumps was 72 and 86 percent after one and two doses, respectively. The vaccine effectiveness against rubella was 89 percent; after two doses in children aged 11 to 22 months, vaccine effectiveness against varicella (any severity) was 95 percent in a 10-year follow-up. The attributable risk for vaccine-induced febrile seizures was estimated to range from one per 1,700 to one per 1,150 administered doses. No evidence was seen for an association between MMR immunization and encephalitis, encephalopathy, or autism spectrum disorders.

"Overall, we think that existing evidence on the safety and effectiveness of MMR/MMRV/MMR+V vaccines supports their use for mass immunization," Di Pietrantonj said in a statement.

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