Cognitive Impairment Linked to Worse Outcomes in Chronic Kidney Disease

FRIDAY, April 24, 2026 (HealthDay News) -- For patients with chronic kidney disease (CKD), cognitive impairment (CI) is associated with worse outcomes, according to a study published in the May issue of Kidney International Reports.Hélène Levassort, M.D., from the Assistance Publique -- Hôpitaux de Paris, and colleagues examined the specific impact of CI on adverse outcomes in CKD in a cohort that included 3,033 patients with CKD stage 2 to 5 and five years of follow-up. The Mini-Mental State Examination (MMSE) was used to assess CI.The analysis included 3,004 patients; at baseline, 64, 23, and 13 percent had MMSE scores >26, 24 to 26, and 26, those with MMSE <24 had a higher risk for clinical adverse outcome in adjusted Cox models (hazard ratios, 1.42, 1.57, and 1.32 for KRT initiation, all-cause mortality, and MACE, respectively). In the group with MMSE of 24 to 26, CI was associated with all-cause mortality (hazard ratio, 1.45)."Our present findings highlight the prognostic value of cognitive status in CKD and suggest that a systematic cognitive assessment would be of relevance in routine nephrology care," the authors write.CKD-REIN is supported by a public-private partnership, with funding from 10 listed pharmaceutical companies; two authors disclosed ties to the pharmaceutical industry.Abstract/Full Text.Sign up for our weekly HealthDay newsletter

Cognitive Impairment Linked to Worse Outcomes in Chronic Kidney Disease

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