TUESDAY, Feb. 21 (HealthDay News) -- A comparison of sildenafil monotherapy, sildenafil plus a topical anesthetic, the anesthetic alone, and a placebo suggests that only topical anesthetic is effective in the treatment of premature ejaculation, according to study results published in the February issue of Urology.
Altug Tuncel, M.D., and colleagues at Ankara Numune Research and Training Hospital in Ankara, Turkey, studied 84 patients with premature ejaculation with a mean duration of 32.5 months. Patients were randomized to 50 mg of sildenafil 45 minutes before intercourse, sildenafil plus EMLA cream (lidocaine 2.5 percent/prilocaine 2.5 percent) applied to the glans penis 15 minutes before intercourse, the topical anesthetic agent alone, or a placebo. The study's duration was two months.
Sildenafil alone was no more effective than placebo, with response rates of 55 percent and 40 percent, respectively. The two topical anesthetic arms were equally and significantly effective. The anesthetic alone had a 77.3 percent response rate and the anesthetic plus sildenafil had a response rate of 86.4 percent, which were not significantly different.
The topical anesthetic agent alone "seems a reasonable, inexpensive and effective treatment modality for premature ejaculation treatment," the authors conclude.
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