WEDNESDAY, Aug. 1 (HealthDay News) -- Body mass index and the number of large ovarian follicles can help predict serum concentrations of human chorionic gonadotropin (hCG) after controlled ovulation, according to a study in the July issue of Fertility and Sterility.
Laura Detti, M.D., of Wayne State University School of Medicine, Detroit, and colleagues observed 115 women who had undergone ovarian hyperstimulation. On the day of ovulation triggering, graduated doses of hCG (5,000-IU, 10,000-IU, or 15,000-IU) were self-administered, according to the number and size of follicles and estradiol levels.
After adjusting for dosage, they found that higher body mass index and a higher number of follicles greater than 14 mm were predictive of lower serum hCG 10 hours to 14 hours after administration. The study found no correlation between hCG levels and patient age, estradiol peak, number of oocytes retrieved and length of stimulation.
"Our findings will help in deciding the correct hCG trigger dose
based on the patient's BMI, because leaner patients will reach higher serum hCG levels than overweight patients with comparable ovulation induction characteristics; as previously suggested, this might make these women more susceptible to developing ovarian hyperstimulation syndrome (OHSS)," the authors concluded. "Future studies will be needed to determine whether titration of the hCG trigger dose based on the
patient's BMI and number of bigger follicles could help prevent the development of OHSS."
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