WEDNESDAY, March 5, 2025 (HealthDay News) -- Uric acid levels are not associated with peripheral vertigo diseases, namely benign paroxysmal positional vertigo (BPPV), Meniere disease (MD), and vestibular neuritis (VN), according to a study published online Jan. 30 in Clinical Otolaryngology.
Shihan Liu, from The Second Affiliated Hospital of Chongqing Medical University in China, and colleagues used the Mendelian randomization (MR) approach to examine the potential link between uric acid levels and peripheral vertigo diseases (BPPV, MD, and VN). Datasets pertaining to uric acid levels and BPPV (3,834 cases; 209,582 controls), MD (1,511 cases; 209,582 controls), and VN (1,224 cases; 209,582 controls) were selected from genome-wide association studies. The correlation between exposure and outcomes was analyzed using two-sample MR. The primary analytical outcomes were the results derived from the inverse variance weighting analysis.
The researchers observed no significant correlations between uric acid levels and BPPV, MD, and VN.
"Although our study did not identify uric acid as an independent risk factor for vertigo, the insights gained can still inform clinical practice. Clinicians should be cautious in attributing vertigo symptoms solely to hyperuricemia without considering other potential causes," the authors write. "Further research into the complex interplay between uric acid, inflammation, and inner ear health will be crucial for developing novel therapeutic targets for vertigo."
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