THURSDAY, July 1 (HealthDay News) -- People with systemic lupus erythematosus (SLE) have higher levels of oxidative and nitrosative stress markers, and the levels of markers appear to increase with the degree of disease activity, according to research published in the July issue of Arthritis & Rheumatism.
Gangduo Wang, M.D., of the University of Texas Medical Branch in Galveston, and colleagues evaluated the sera of 72 patients with SLE and 36 controls for the presence of oxidative/nitrosative markers.
The researchers found that the subjects with SLE had significantly higher levels of anti-malondialdehyde- and anti-hydroxynonenal-protein adduct antibodies. The higher the patient's disease activity according to their SLE disease activity index (SLEDAI), the higher the antibodies, suggesting a causal relationship. Sera from patients with SLE also had higher levels of inducible nitric oxide synthase and lower levels of superoxide dismutase.
"Our findings support an association between oxidative/nitrosative stress and SLE. Stronger response in samples with higher SLEDAI suggests that oxidative/nitrosative stress markers may be useful in evaluating the progression of SLE as well as in elucidating the mechanisms of disease pathogenesis," the authors write.
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