Newer Migraine Drugs Reduce Headache Days With Fewer Side Effects

Key TakeawaysNew research shows CGRP-targeted therapies can help migraine sufferers These medications block a protein that spikes during migraines, triggering painResearchers found drawbacks to Botox, a common migraine treatment.TUESDAY, May 5, 2026 (HealthDay News) — Chronic migraine can be difficult to treat — but new research is helping identify the most effective options.In a large new review, published today in the Annals of Internal Medicine, researchers analyzed 43 clinical trials involving adults with chronic migraine, defined as headaches on 15 or more days a month.The strongest evidence pointed to a newer class of medications called CGRP-targeted therapies, according to the results. These drugs were shown to reduce monthly migraine days by about two and were generally well tolerated. Examples of CGRP-targeted therapies include eptinezumab (brand name, Vyepti) and atogepant (Qulipta).CGRP is a protein found in the brain and nervous system that spikes during migraines, triggering pain and inflammation. The drugs are designed to block that process.Available as shots, infusions, pills and a nasal spray, the drugs were also found to have fewer side effects than older treatments.By comparison, the evidence showed botulinum toxin, or Botox, may offer some benefit but with less certainty and more side effects, leading to treatment drop-off. For older medications like topiramate, valproate and propranolol, the evidence was also limited and even less reliable.The researchers say more independent studies on CGRP therapies are needed, especially on long-term safety and adherence.They add that while newer therapies appear to show the most promise, the right treatment depends on a patient's individual needs and preferences, as well as cost. They recommend talking with your health care provider to find the best option.Malahat Khalili of the Michael G. DeGroote Institute for Pain Research and Care at McMaster University in Hamilton, Ontario, Canada, led the study.More informationThe Cleveland Clinic has more on CGRP inhibitors.SOURCE: HealthDay TV, May 5, 2026 .What This Means For YouIf you suffer from migraines, newer drugs are available that may lead to fewer headache days a month as well as fewer side effects..Sign up for our weekly HealthDay newsletter

Newer Migraine Drugs Reduce Headache Days With Fewer Side Effects

Related Stories

Chronic Immune-Related AEs Common in Patients With Melanoma Receiving Anti-PD-1 Therapy

AI Tool Predicts Prolonged Sitting In Women With Pelvic Pain, Promotes Activity

Exercise As Medicine: How Physical Activity Helps Manage Chronic Disease

New Class Of Weight-Loss Drugs May Have Fewer Side Effects Than GLP-1s