WEDNESDAY, Mar. 11 (HealthDay News) -- In patients with acute coronary syndrome, those with diabetes have greater inflammatory status and more plaques with signs of vulnerability, according to research published in the March issue of the Journal of the American College of Cardiology: Cardiovascular Imaging.
Young Joon Hong, M.D., Ph.D., of the Chonnam National University Research Institute of Medical Sciences in Gwangju, Korea, and colleagues analyzed intravascular ultrasound and virtual histology intravascular ultrasound data from 310 patients with acute coronary syndrome. Of these patients, 112 had acute myocardial infarction with plaque ruptures. Some of the patients in the analyses had diabetes, and some did not.
High-sensitivity C-reactive protein was higher in diabetic patients, who were also more likely to have multivessel disease and had a higher plaque burden, the investigators found. In the group with acute myocardial infarction and plaque ruptures, multiple plaque ruptures and thrombi were more common in those with diabetes. In multivariable analysis, diabetes remained an independent predictor of C-reactive protein elevation and multiple plaque ruptures, the researchers report.
"Diabetic patients with acute coronary syndrome have more plaques and have characteristics of plaque vulnerability and a different composition of plaques and greater inflammatory status compared with non-diabetic acute coronary syndrome patients. The intravascular ultrasound features of vascular disease consistent with plaque vulnerability and rupture are more prevalent in diabetics likely due to the type of vascular involvement in this diffuse disease," the authors conclude.
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