Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for October 2007. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Low Testosterone Linked with Higher Risk of Death
TUESDAY, Oct. 30 (HealthDay News) -- Men with low testosterone levels are more likely to die earlier than men with high testosterone levels, according to a report that will appear in the December issue of the Journal of Clinical Endocrinology & Metabolism.
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Diabetics Show Improvements in Ischemia Over Three Years
MONDAY, Oct. 29 (HealthDay News) -- In a majority of people with type 2 diabetes and myocardial ischemia, the ischemia resolved during a three-year span, which was an unexpected development associated with intensive treatment, according to study findings reported in the November issue of Diabetes Care.
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Long-Lasting Epoetin Effective for Renal Anemia
FRIDAY, Oct. 26 (HealthDay News) -- A long-lasting pegylated epoetin given every four weeks is as effective as standard epoetin given several times a week in maintaining hemoglobin within a target range in patients with chronic renal anemia, according to the results of a study published in the Oct. 20 issue of The Lancet.
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Vibrations Reduce Fat Cell Production in Mice
THURSDAY, Oct. 25 (HealthDay News) -- Mice receiving brief daily treatments of high-frequency vibrations well below what would occur during walking have reduced production of fat cells, according to a report published online Oct. 24 in the Proceedings of the National Academy of Sciences Early Edition.
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Program Benefits Chronic Hemodialysis Patients
THURSDAY, Oct. 25 (HealthDay News) -- An early intervention program that promotes medical and educational strategies reduces hospital stays and lowers mortality in chronic hemodialysis patients, according to a report in the November issue of the Clinical Journal of the American Society of Nephrology.
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Gender Disparities Seen in Post-MI Fibrinolytic Treatment
THURSDAY, Oct. 25 (HealthDay News) -- Among heart attack patients who receive fibrinolytic treatment, female sex is independently associated with an increased risk of death and bleeding complications, researchers report in the Oct. 22 issue of the Archives of Internal Medicine.
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Glycemic Control Suboptimal with a Single Insulin Type
WEDNESDAY, Oct. 24 (HealthDay News) -- Adding a single analogue-insulin formulation to the treatment of individuals with diabetes who are failing oral therapy leads to target glycemic control in a minority of individuals, according to a report published in the Oct. 25 issue of the New England Journal of Medicine.
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Growing Waist Circumferences Are a Worldwide Problem
WEDNESDAY, Oct. 24 (HealthDay News) -- A major endeavor to take a snapshot of the state of obesity around the globe found that excess weight was pandemic in most areas and that abdominal obesity had a graded relationship with cardiovascular disease and diabetes. The study was published in the Oct. 23 issue of Circulation: Journal of the American Heart Association.
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Specific Goals Are Key for School Food Programs
WEDNESDAY, Oct. 24 (HealthDay News) -- School feeding programs are most effective when they are aimed at children with documented nutritional deficiencies and when they are designed in partnership with members of the local community, rather than by distant experts, according to a review of studies published in the October issue of the Cochrane Database of Systematic Reviews.
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Insulin Clue for Amphetamine Abuse Treatment
MONDAY, Oct. 22 (HealthDay News) -- Rats that have been depleted of insulin self-administer less amphetamine compared with those with normal insulin levels, which suggests a potential new mechanism for treatment of amphetamine abuse through insulin signaling pathways, according to a study published online Oct. 16 in PLoS Biology.
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Multiple Factors Affect Diabetic Muscle Gene Expression
FRIDAY, Oct. 19 (HealthDay News) -- The expression of a gene that is reduced in the muscle of diabetic patients is affected by genetic, epigenetic and non-genetic factors, according to a report published online Oct. 18 in the Journal of Clinical Investigation.
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Foundation Discusses Thyroid Growths in Pregnancy
FRIDAY, Oct. 19 (HealthDay News) -- In order to provide information and reassurance to pregnant women with thyroid nodules and cancer, The Hormone Foundation -- the public education affiliate of the Endocrine Society -- has created a patient guide covering the subject, published in the October issue of the Journal of Clinical Endocrinology & Metabolism and the November issue of Endocrine News.
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Mentally Ill Suffer Increased Cardiovascular Disease Risk
THURSDAY, Oct. 18 (HealthDay News) -- People with severe mental illness are over-represented in the rates of cardiovascular disease and receive inferior care compared to the general population, according to a commentary published in the Oct. 17 issue of the Journal of the American Medical Association.
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Postmenopausal Progesterone Impacts Vascular Function
THURSDAY, Oct. 18 (HealthDay News) -- Increased concentrations of progesterone in postmenopausal women in low-sodium balance blunt pressor and renovascular responses to infused angiotensin II, according to a report published online Sept. 25 in the Journal of Clinical Endocrinology & Metabolism.
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Iron Improves Outcomes of Heart and Kidney Failure
TUESDAY, Oct. 16 (HealthDay News) --Anemic patients with heart and kidney failure have improved clinical outcome and quality of life after treatment with intravenous iron without erythropoietin, according to a study published online Oct. 6 in the Journal of the American College of Cardiology.
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Statins Improve Outcomes After Vascular Surgery
TUESDAY, Oct. 16 (HealthDay News) -- Higher statin dose and lower low-density lipoprotein (LDL) cholesterol are associated with decreased rates of myocardial ischemia, troponin T release, and early and late cardiac events after vascular surgery, according to a study published online Oct. 6 in the Journal of the American College of Cardiology.
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Weight Loss Prior to Gastric Bypass Improves Results
TUESDAY, Oct. 16 (HealthDay News) --Losing 5 percent to 10 percent of excess body weight before gastric bypass surgery may help shorten hospital stays and increase the odds of substantial weight loss in the following year, researchers reported in the October Archives of Surgery.
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Novel Topical Oxygen Emulsion Shows Promise for Wounds
TUESDAY, Oct. 16 (HealthDay News) --A novel topical oxygen emulsion which slowly releases oxygen over time has shown promise in the treatment of second-degree burns and acute partial thickness wounds in a pig model, according to research published in Archives of Dermatology in October.
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Drug-Eluting Stents Effective in Diabetics
TUESDAY, Oct. 16 (HealthDay News) -- Sirolimus-eluting stents are both safe and highly effective for patients with coronary artery disease and diabetes mellitus, according to a study published online Oct. 6 in the Journal of the American College of Cardiology.
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High Food Reinforcement Plus Genotype Boost Calorie Intake
MONDAY, Oct. 15 (HealthDay News) -- People who find food very reinforcing and who have the dopamine D2 receptor genotype ingest more calories than people without those traits, suggesting that both factors may combine to affect energy consumption, researchers report in the October issue of Behavioral Neuroscience.
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Narcolepsy Linked with Higher BMI, Eating Disorder
FRIDAY, Oct. 12 (HealthDay News) -- Patients with narcolepsy are more likely to be overweight and have lower basal metabolism than people without the disorder; the greater weight may be due to metabolism or eating practices that help them minimize daytime sleepiness, according to research published in the Oct. 1 issue of the journal Sleep.
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High Blood Pressure Increases Women's Diabetes Risk
FRIDAY, Oct. 12 (HealthDay News) -- Women with high blood pressure or whose blood pressure increases over time have a greater risk of developing type 2 diabetes, according to study findings published online Oct. 9 in the European Heart Journal.
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Trendy Weight-Loss Plans Yield Varying Dietary Quality
THURSDAY, Oct. 11 (HealthDay News) -- Dietary quality, or how much a diet cuts chronic disease risk, varies substantially among popular weight-loss plans, researchers report in the October issue of the Journal of the American Dietetic Association.
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FDA Modernizes Generic Drug Approval Process
WEDNESDAY, Oct. 10 (HealthDay News) -- To help modernize and streamline the generic drug approval process, the U.S. Food and Drug Administration launched a new program -- Generic Initiative for Value and Efficiency, or GIVE -- on Oct. 4. The program is intended to increase the number and variety of generic drug products available to physicians and patients.
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Disparities Found Between Medicaid, Commercial Patients
WEDNESDAY, Oct. 10 (HealthDay News) -- Enrollees in Medicaid managed-care programs receive a poorer quality of health care than those in commercial managed-care programs, based on a variety of quality indicators, researchers report in the Oct. 10 issue of the Journal of the American Medical Association.
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Kids' Weight Maintenance Plans Less Effective Over Time
TUESDAY, Oct. 9 (HealthDay News) -- Weight-maintenance programs helped children control their weight over a four-month period following weight-loss treatment, although these effects waned over long-term follow-up, according to research presented in the Oct. 10 Journal of the American Medical Association.
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Relaxin Regulates Airway Responses in Mice
TUESDAY, Oct. 9 (HealthDay News) -- Relaxin, a reproductive hormone, appears to regulate airway remodeling, and mice deficient in the hormone develop airway changes similar to those seen by inducing allergic airways disease, according to a report published in the September issue of Endocrinology.
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Benefits of Anti-Soft Drink Campaign Diminish Over Time
TUESDAY, Oct. 9 (HealthDay News) -- A year-long program promoting a healthy diet and discouraging soft-drink intake in children aged 7 to 11 helped reduce rates of overweight and obesity, but these benefits were not sustained after a two-year follow-up, according to a report published online Oct. 8 in BMJ.
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Siblings Share Risk of Left Main Coronary Artery Disease
TUESDAY, Oct. 9 (HealthDay News) -- Asymptomatic siblings of patients with left main coronary artery disease are at increased risk of developing the same condition, according to a report published online Oct. 3 in the European Heart Journal.
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Diabetic Platelet Reactivity Increases Cardiovascular Risk
TUESDAY, Oct. 9 (HealthDay News) -- Patients with type 2 diabetes mellitus and coronary artery disease chronically treated with anti-platelet therapy are at higher risk of major cardiovascular events if they have high platelet reactivity, according to a report published online Oct. 1 in the Journal of the American College of Cardiology.
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Obesity Influences Frequency of Migraine Headaches
MONDAY, Oct. 8 (HealthDay News) -- Obesity appears to be associated with migraine headaches but not necessarily with other types of episodic headaches, researchers report in the Oct. 8 issue of the Archives of Internal Medicine.
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Government Increases Potency Standards for Thyroid Drugs
FRIDAY, Oct. 5 (HealthDay News) -- Concern that levothyroxine sodium products may degrade to unacceptable levels prior to their expiration date has prompted the U.S. Food and Drug Administration to tighten potency standards for these products, which are used to treat 13 million U.S. patients with thyroid conditions, according to an action announced Oct. 3.
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Risk Assessment is Difficult for Young Adults with Diabetes
FRIDAY, Oct. 5 (HealthDay News) -- An attempt to devise a risk assessment tool for predicting the development of diabetes in young adults proved unsuccessful, researchers report in the September/October issue of the Annals of Family Medicine.
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Polycystic Ovary Syndrome Linked to Hepatic Steatosis
FRIDAY, Oct. 5 (HealthDay News) -- Women with polycystic ovary syndrome are more likely to have non-alcoholic fatty liver disease, confirming a clinical association between the two conditions, researchers report in the September issue of the Journal of Hepatology.
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Tissue Protease Suppression of Value in Brain Hemorrhage
THURSDAY, Oct. 4 (HealthDay News) -- Suppression of matrix metalloproteinase-9 may attenuate vascular endothelial growth-factor induced intracerebral hemorrhage, suggesting that matrix metalloproteinase-9 inhibitors may be of use in treating cerebral vascular rupture, according to the results of an animal study published in the September issue of Stroke.
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Atherosclerosis Involves Inflammatory T cells
THURSDAY, Oct. 4 (HealthDay News) -- Atherosclerosis is a disease involving not only lipid deposition but also an inflammatory response mediated by various T-cell subsets, according to an editorial comment published in the Oct. 9 issue of the Journal of the American College of Cardiology.
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Caloric Restriction Response in Females May Explain Anorexia
TUESDAY, Oct. 2 (HealthDay News) -- Caloric restriction in female mice results in reproductive shutdown and increased cognition and motor activity, increasing their chances of survival, which may explain why females are more susceptible to developing anorexia, according to the results of a study published in the September issue of Endocrinology.
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Higher Risk of Heart Failure After Diabetes Treatment
TUESDAY, Oct. 2 (HealthDay News) -- Pre-diabetic and diabetic patients taking thiazolidinediones for glycemic control nearly double their risk of congestive heart failure with no change in the risk of cardiac death, researchers report in the Sept. 29 issue of The Lancet.
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Physical Activity Levels Decline Through High School
MONDAY, Oct. 1 (HealthDay News) -- By high school, physical education and sports participation dramatically declines, and the drop is especially pronounced among students with lower socioeconomic status, and black and Hispanic students, who are already at higher risk of being overweight or obese, according to a report published in the October issue of the American Journal of Preventive Medicine.
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